More Falls for Those Starting Newer Antipsychotics

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Falls, fractures up 50% in patients with new prescriptions for atypical antipsychotics.

Receiving a new prescription for an atypical antipsychotic medicine was associated with more serious falls and more fractures in a new retrospective cohort study.

Adults ages 65 and older who received a new prescription had a 53% increased risk of falling and a 50% increased risk of nonvertebral osteoporotic fracture, found the study. It was published as a research letter in JAMA Internal Medicine on Jan. 13, 2015, and was led by Lisa-Ann Fraser, MD, from the University of Western Ontario in Canada.

“These findings call into question the widespread off-label use of atypical antipsychotic medications and support increasing evidence of safety concerns regarding their use in older adults,” Fraser and colleagues wrote.

In the retrospective study of 200,000 residents of Ontario, whose medical records are kept in a central database, those who received a new prescription…

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